研究業績(1998〜)
Hori, Y, Shimoto, A, and Kobayashi, T. (2021). The human ribosomal DNA array is composed of highly homogenized tandem clusters. Genome res. doi:10.1101/gr.275838.121
Iida, T. Iida, N. Sese. J. and Kobayashi, T. (2021) Evaluation of repair activity by quantification of ribonucleotides in the genome. Genes Cells, 26, 555-569
Iida, T. and Kobayashi, T. (2021) Establishment of an “in saccharo” experimental system. Genes Genet. Systems, doi:https://doi.org/10.1266/ggs.21-00004
Goto, M., Sasaki, M., and Kobayashi, T. (2021) The S-Phase Cyclin Clb5 Promotes rRNA Gene (rDNA) Stability by Maintaining Replication Initiation Efficiency in rDNA Mol. Cell. Biol., DOI: https://doi.org/10.1128/MCB.00324-20
Mostofa M, Morshed S, Mase S, Hosoyamada S, Kobayashi T, Ushimaru T (2021) Cdc14 protein phosphatase and topoisomerase II mediate rDNA dynamics and nucleophagic degradation of nucleolar proteins after TORC1 inactivation Cellular Signalling 79 DOI: 10.1016/j.cellsig.2020.109884
Watada, E., Li, S., Hori, Y, Fujiki, K., Shirahige, K., Inada,T., and Kobayashi, T. (2020) Age-dependent ribosomal DNA variations in mice. Mol. Cell. Biol., 40 e00368-20 プレスリリース
Hosoyamada, S., Sasaki, M., and Kobayashi, T. (2019) The CCR4-NOT complex maintains stability and transcription of ribosomal RNA genes by repressing anti-sense transcripts. Mol. Cell. Biol., 40, e0032-19
Mostofa, M.G, Morshed, S.,Shibata, R., Takeichi, Y., Rahman, M.A., Hosoyamada, S, Kobayashi T, and Ushimaru T. (2019) rDNA condensation promotes rDNA separation from nucleolar proteins degraded for nucleophagy after TORC1 inactivation. Cell Reports, 28, 3423-3434.プレスリリース10.1016/j.celrep.2019.08.059.
Wakatsuki, T., Sasaki, M., and Kobayashi, T. (2019) Defects in the NuA4 acetyltransferase complex increases stability of the ribosomal RNA gene and extends replicative lifespan. Genes Genet. Systems, 94, 197-206 https://doi.org/10.1266/ggs.19-00022
Horigome, C., Unozawa, E., Ooki, T., and Kobayashi, T. (2019) Ribosomal RNA gene repeats associate with the nuclear pore complex for maintenance after DNA damage. PLOS Genet. 15(4):e1008103プレスリリース 10.1371/journal.pgen.1008103
Iida, T., and Kobayashi, T. (2019) How do cells count multi-copy genes?: “Musical Chair” model for preserving the number of rDNAcopies. Curr Genet. doi: 10.1007/s00294-019-00956-0
Kobayashi, T. (2016) Genome Instability of Repetitive Sequence: Lesson from the Ribosomal RNA Gene Repeat. “DNA Replication, Recombination, and Repair” Hanaoka, F and Sugasawa K. ed. Part IV, Chapter 10: 235-247.
Ide, S., Miyazaki, T., Maki, H., and Kobayashi, T. (2010). Abundance of ribosomal RNA gene copies maintains genome integrity. Science 327, 693-696.
Ganley, A.R.D., Ide, S., Saka, K., and Kobayashi, T. (2009). The effect of replication initiation on gene amplification in the rDNA and its relationship to aging. Molecular Cell , 35, 683-693.
Iida, T., Nakayama, J. and Moazed, D. (2008). siRNA-mediated heterochromatin establishment requires HP1 and is associated with antisense transcription. Molecular Cell. 31, 178-189.
Kobayashi, T. (2008). A new role of the rDNA and nucleolus in the nucleus- rDNA instability maintains genome integrity-. BioEssays 30, 267-272.
Ganley, A.R.D. and Kobayashi, T. (2007). Phylogenetic footprinting to find functional DNA elements. Methods in Molecular Biology, Comparative Genomics v.1, Humana press, 367-379.
Ganley, A.R.D. and Kobayashi, T. (2007). Highly efficient concerted evolution in the ribosomal DNA repeats: Total rDNA repeat variation revealed by whole-genome shotgun sequence data. Genome Res. 17, 184-191
Ide, S., Watanabe, K., Watanabe, H., Shirahige, K., Kobayashi, T., and Maki, H. (2007). Abnormality in initiation program of DNA replication is monitored by the highly repetitive rRNA gene array on chromosome XII in budding yeast. Mol Cell Biol. 27, 568-578.
Kobayashi, T. (2006). Strategies to maintain the stability of the ribosomal RNA gene repeats. Genes Genet. Syst. 81, 155-161.
Kobayashi. T. and Ganley, A. R. D. (2005). Recombination regulation by transcription-induced cohesin dissociation in rDNA repeats. Science, 309, 1581-1584.
Ganley, A. R. D., Hayashi, K., Horiuchi, T. and Kobayashi, T. (2005). Identifying gene-independent noncoding functional elements in the yeast ribosomal DNA by phylogenetic footprinting. Proc. Natl. Acad. Sci. USA, 102, 11787-11792.
Kobayashi, T., Horiuchi, T., Tongaonkar, P., Vu, L., and Nomura, M. (2004). SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast.Cell, 117, 441-453.
Serizawa, N., Horiuchi, T., and Kobayashi, T. (2004). Transcription-mediated hyper-recombination in HOT1. Genes Cells, 9, 305-315.
Kobayashi, T. (2003). The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork. Mol. Cell. Biol. 23, 9178-9188.
Takeuchi, Y., Horiuch, T. and Kobayashi, T. (2003). Transcription-dependent recombination and the role of fork collision in yeast rDNA. Genes Dev. 17, 1497-1506.
Morehouse, E., James, T.Y., Ganley, A.R.D., Vilgalys, R., Berger, L., Murphy, P.J., and Longcore, J.E. (2003). Multilocus sequence typing suggests the chytrid pathogen of amphibians is a recently emerged clone. Molecular Ecology, 12, 395-403.
Kodama, K.-i., Kobayashi, T., Niki, H., Hiraga, S., Oshima, T., Mori, H., and Horiuchi, T. (2002). Amplification of Hot DNA segments in Escherichia coli. Mol. Microbiol. 45, 1575-1588.
Ganley, A.R.D., and Scott, B. (2002). Concerted evolution in the ribosomal RNA genes of an Epichloe endophyte hybrid. Comparison between tandemly-arranged rDNA and dispersed 5S rrn genes. Fungal Genetics and Biology, 35, 39-51.
Wai, H., Johzuka, K., Vu, L., Eliason, K., Kobayashi, T., Horiuchi, T., and Nomura, M.(2001). Yeast RNA polymerase I enhancer is dispensable for transcription of the chromosomal rRNA gene and cell growth, and its apparent transcription enhancement from ectopic promoters required Fob1 protein. Mol. Cell. Biol. 21, 5541-5553.
Kobayashi, T., Nomura, M., and Horiuch, T. (2001). Identification of DNA cis-elements essential for expansion of ribosomal DNA repeats in Saccharomyces cerevisiae: Mol. Cell. Biol 21, 136-147.
Rein, T., Kobayashi, T., Malott, M., Leffak, M., and DePamphilis. M. L. (1999). DNA methylation at mammalian replication origins. J. Biol. Chem. 274, 25792-25800.
Kobayashi, T., Heck, D.J., Nomura, M., and Horiuch, T. (1998). Expansion and contraction of ribosomal DNA repeats in Saccharomyces cerevisiae: requirement of replication fork blocking (Fob1) protein and the role of RNA polymerase I. Genes Dev. 12, 3821-3830.
Ganley, A.R.D. and Scott, B. (1998). Extraordinary ribosomal spacer length heterogeneity in a Neotyphodium endophyte hybrid: Implications for concerted evolution. Genetics, 150, 1625-1637.
Kobayashi, T., Rein, T., and DePamphilis, M. L. (1998). Identification of primary initiation sites for DNA replication in the hamster dihydrofolate reductase gene intiation zone. Mol. Cell. Biol. 18, 3266-3277.
最近の日本語の総説(2001〜)
小林武彦(2017)「遺伝学はこんなに面白い!─多様性の学問としての遺伝学」 生物の科学「遺伝」7月号No.4, p308-313
小林 武彦(2014) 遺伝子が語る生命38億年の謎―なぜ、ゾウはネズミより長生きか? (共著)国立遺伝学研究所編 悠書館
小林 武彦 (2013)「染色体の安定性の鍵を握る反復配列の維持機構」実験医学vol.31, 2573-2577.
小林 武彦、他、(2013) 「遺伝子図鑑」 国立遺伝学研究所編、編者及び著者、悠書館
小林 武彦、赤松 由布子(2013)「リボソームRNA遺伝子の不安定性と生理作用」生化学、第85巻10号839-844
小林 武彦 他(2013)「岩波生物学辞典」第5版 編者及び著者
小林 武彦 (2012)「rDNA巨大反復遺伝子群による細胞老化制御」実験医学 Vol.30、2228-2233.
小林 武彦 (2012)「今開かれる非コードDNA領域の世界」実験医学 Vol.30、2202-2207.
小林 武彦(2011)「核小体の新機能」生体の科学 vol.62、医学書院、412-415
小林 武彦(2011)「リボソームRNA遺伝子不安定性と細胞老化」生体の科学 vol.62、医学書院、416-417
小林武彦(2010)老化モデル「酵母」新老年学 第3版、2章2.4、東京大学出版会pp265-271
小林 武彦 (2009)「複製、組換え、転写のコラボレーションによる遺伝子増幅」 蛋白質、核酸、酵素、54, 2009, 537-542
小林 武彦 (2009)「リボソームRNA遺伝子の新しい機能」 化学と生物、47・2, 2009, 104-110
小林 武彦(2007)「複製ファークと組換えの共役による遺伝子増幅の制御」実験医学 増刊
Vol.25、635-641.
小林 武彦、Austen R.D. Ganley (2007)「系統発生学的フットプリントによる機能性DNA配列の同定」 遺伝 別冊vo.21、265-268
小林 武彦(2006)「noncodingな転写がrDNAのコピー数を調節する」 蛋白質・核酸・酵素、増刊号『細胞核の世界』、Vol.51、2141-2143.
小林 武彦(2006)「rDNAの恒常性の維持機構」 細胞工学、Vol.25 (5月号)、481?485.
小林 武彦(2006)「酵母の老化制御機構」 医学のあゆみ、217巻、7号、743?747.
小林 武彦(2006)「ゲノムを変化させる遺伝子増幅」 総研大ジャーナル、9号(3月号)、p8-10.
小林 武彦(2005) 「酵母を使った老化研究?rDNA仮説を中心にー」 基礎老化研究Vol.29、p7-11.
小林 武彦(2004)「SIR2は姉妹染色分体間結合を介してリボゾームRNA遺伝子を安定化している。」 実験医学、vol. 22、pp1835-1838.
小林 武彦、竹内 靖、定塚 勝樹、堀内 嵩(2001)「DNA複製フォークの進行阻害と遺伝子の増幅」 蛋白質・核酸・酵素、vol. 46、pp1004-1012.